Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 102, Issue 1, Pages 151-156Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2012.04.003
Keywords
Beta-adrenoceptors; Dopamine D2-like receptors; Learning; Pharmacology
Funding
- GACR [P303/10/J032, P304/12/G069]
- IGA MZ CR [NT/13386]
- RVO [67985823, AV0Z50110509]
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Spatial navigation attracts the attention of neuroscientists as an animal analogue of human declarative memory. The Carousel maze is a dry-land navigational paradigm, which proved to be useful in studying neurobiological substrates of learning. The task involves avoidance of a stable sector on a rotating arena and is highly dependent upon the hippocampus. The present study aims at testing hypothesis that sulpiride (a centrally-active dopamine D2-like receptor antagonist) and propranolol (a beta-blocker) impair spatial learning in the Carousel maze after combined systemic administration. These doses were previously shown to be subthreshold in this task. Results showed that both substances affected behavior and significantly potentiated their negative effects on spatial learning. This suggests central interaction of both types of receptors in influencing acquisition of this dynamic-environment task. (c) 2012 Elsevier Inc. All rights reserved.
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