Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 91, Issue 4, Pages 560-565Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2008.09.017
Keywords
Adolescent; Adult; Ethanol; Blood alcohol level; Pharmacokinetics; Gavage; Intraperitoneal
Funding
- NIAAA NIH HHS [AA014339, R01 AA014339, R01 AA014339-05, AA006059, R01 AA006059-18, R01 AA006059] Funding Source: Medline
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Knowledge of blood alcohol levels (BALs) that are achieved following ethanol administration is critical for contemporary efforts to develop animal models of alcoholism. Adolescent and adult male Wistar rats were administered varying doses of ethanol (0.75, 1.5 and 3.0 g/kg) via gavage or intraperitoneal injection and BALs were measured over a two hour period. The results showed that adolescent animals had lower BALs across all time points in comparision to adults following administration of 0.75 g/kg ethanol and that 1 h after administration of 1.5 g/kg ethanol, adolescent animals showed all enhanced rate of elimination. The highest dose of ethanol (3.0 g/kg) produced comparable BALs for both adolescents and adults during the two-hour sampling period: however, the BALs for both ages were lower following administration of ethanol by gavage at this dose. Furthermore, an order effects analysis highlights that depending on the route of administration, initial dose size can influence the BALs produced by lower doses of ethanol. The current data identify the importance of measuring the level of alcohol in the blood to confirm that target BALs are achieved for adolescents and equivalent BALs are being reached for both adolescent and adult animals when such comparisons are made. (c) 2008 Elsevier Inc. All rights reserved.
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