Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 92, Issue 4, Pages 559-565Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2009.04.001
Keywords
Marijuana; Cannabis; Adolescence; THC; Drug abuse; Neuropsychological assessment; Magnetic resonance imaging; Sleep
Funding
- NIDA [R01 DA021182, P20 DA024194, F32 DA024476]
- NIAAA [51101 AA13419, T32 AA013525]
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Nearly half of 12th graders have tried marijuana, and 6% use daily. This paper reviews studies on neuropsychological functioning, brain structure, brain function, and subjective and objective measures of sleep in relation to adolescent marijuana use. Adolescents who use marijuana heavily tend to show disadvantaged attention, learning, and processing speed; subtle abnormalities in brain structure; increased activation during cognitive tasks despite intact performance: and compromised objective indicators of sleep quality. Some abnormalities appear to persist beyond a month of abstinence, but may resolve within three months if cessation is maintained. Recommendations for future studies include characterizing these indices in Youth prior to the onset of marijuana use then examining change after chronic use has started, and using large samples Of Youth with varying degrees of involvement with marijuana as well as alcohol, nicotine, and other drugs to characterize the interactive influences on neurocognition and neural health. Published by Elsevier Inc.
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