Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 93, Issue 1, Pages 40-46Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2009.04.004
Keywords
Adiantum cuneatum; Antinociception; Filicene; Action mechanism
Funding
- CNPq
- FAPESC-SC
Ask authors/readers for more resources
In the present study, we describe the antinociceptive effect of filicene, a triterpene isolated from Adiantum cuneatum (Adiantaceae) leaves, in several models of pain in mice. When evaluated against acetic acid-induced abdominal constrictions, filicene (10, 30 and 60 mg/kg, i.p.) produced dose-related inhibition of the number of constrictions, being several times more potent [ID50=9.17 (6.27-13.18) mg/kg] than acetaminophen [ID50=18.8 (15.7-22.6) mg/kg], diclofenac [ID50=12.1(9.40-15.6) mg/kg] and acetylsalicylic acid [ID50=24.0(13.1-43.8) mg/kg] in the same doses as those used for the standard drugs. Filicene also produced dose-related inhibition of the pain caused by capsaicin and glutamate, with mean ID50 values of 11.7 (8.51-16.0) mg/kg and <10 mg/kg, respectively. Its antinociceptive action was significantly reversed by atropine, haloperidol, GABA(A) and GABA(B) antagonists (bicuculline and phaclofen, respectively), but was not affected by L-arginine-nitric oxide, serotonin, adrenergic and the opioid systems. Together, these results indicate that the mechanisms involved in its action are not completely understood, but seem to involve interaction with the cholinergic, dopaminergic, glutamatergic. GABAergic and tachykinergic systems. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available