Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 90, Issue 3, Pages 387-393Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2008.03.013
Keywords
impulsivity; D-4 receptors; mice; delay discounting; Go/No-go; inhibition; novelty seeking; locomotion
Funding
- NIAAA NIH HHS [P60 AA010760, T32 AA007468-21, T32 AA007468, 5 T32-AA07468] Funding Source: Medline
- NIDA NIH HHS [R01 DA016727-04, R01 DA016727] Funding Source: Medline
- NIMH NIH HHS [MH070219, F31 MH070219-03, R01 MH067497-05, R01 MH067497, MH67497, F31 MH070219] Funding Source: Medline
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Alleles of the human dopamine D-4 receptor (D4R.) gene (DRD4.7) have repeatedly been found to correlate with novelty seeking, substance abuse, pathological gambling, and attention-deficit hyperactivity disorder (ADHD). If these various psycho pathologies are a result of attenuated D4R-mediated signaling, mice lacking D(4)Rs (D4KO) should be more impulsive than wild-type (WT) mice and exhibit more novelty seeking. However, in our study, D4KO and WT mice showed similar levels of impulsivity as measured by delay discounting performance and response inhibition on a Go/No-go test, suggesting that D4R-mediated signaling may not affect impulsivity. D4KO mice were more active than WT mice in the first 5 min of a novel open field test, suggesting greater novelty seeking. For both genotypes, more impulsive mice habituated less in the novel open field. These data suggest that the absence of D(4)Rs is not sufficient to cause psychopathologies associated with heightened impulsivity and novelty seeking. (C) 2008 Elsevier Inc. All rights reserved.
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