4.5 Review

GABAA receptor subtypes underlying general anesthesia

Journal

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 90, Issue 1, Pages 105-112

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2007.12.011

Keywords

anesthesia; GABA; GABA(A) receptors; GABA modulators; THIP; isoflurane; etomidate

Ask authors/readers for more resources

General anesthetics produce a constellation of behavioral responses and widespread neurodepression. Recent studies have implicated the gamma-aminobutyric acid (GABA) subtype A receptor as a primary anesthetic target. During the past decade, considerable progress has been made in dissecting the behavioral effects of anesthetics according to the subunit composition of GABA(A) receptors. In this review, we describe how particular GABA(A) receptor subtypes expressed in different brain regions are critical for the expression of behavioral endpoints, such as amnesia, sedation, and hypnosis. (C) 2007 Elsevier Inc. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available