Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 90, Issue 1, Pages 105-112Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2007.12.011
Keywords
anesthesia; GABA; GABA(A) receptors; GABA modulators; THIP; isoflurane; etomidate
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General anesthetics produce a constellation of behavioral responses and widespread neurodepression. Recent studies have implicated the gamma-aminobutyric acid (GABA) subtype A receptor as a primary anesthetic target. During the past decade, considerable progress has been made in dissecting the behavioral effects of anesthetics according to the subunit composition of GABA(A) receptors. In this review, we describe how particular GABA(A) receptor subtypes expressed in different brain regions are critical for the expression of behavioral endpoints, such as amnesia, sedation, and hypnosis. (C) 2007 Elsevier Inc. All rights reserved.
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