Journal
PHARMACOLOGY & THERAPEUTICS
Volume 144, Issue 3, Pages 303-320Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2014.06.009
Keywords
Nitrate; Nitrite; Nitric oxide; Vasodilatation; Heart failure
Categories
Funding
- UK Medical Research Council [G1001536]
- MRC [G1001536] Funding Source: UKRI
- Medical Research Council [G1001536] Funding Source: researchfish
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Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure. (C) 2014 Elsevier Inc All rights reserved.
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