Journal
PHARMACOLOGY & THERAPEUTICS
Volume 141, Issue 3, Pages 272-282Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2013.10.010
Keywords
Omega-3 polyunsaturated fatty acid; Eicosapentaenoic acid; Docosahexaenoic acid; Inflammation; Eicosanoid; Resolvin
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Funding
- Vifor Pharma
- Biotechnology and Biological Sciences Research Council [BBS/B/01057] Funding Source: researchfish
- British Heart Foundation [PG/09/069/27905] Funding Source: researchfish
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Omega-3 (n-3) polyunsaturated fatty acids (n-3 PUFAs) have well documented anti-inflammatory properties, and consequently therapeutic potential in chronic inflammatory diseases. Here we discuss the effects of n-3 PUFAs on various inflammatory pathways and how this leads to alterations in the function of inflammatory cells, most importantly endothelial cells and leukocytes. Strong evidence indicates n-3 PUFAs are beneficial as a dietary supplement in certain diseases such as rheumatoid arthritis; however for other conditions such as asthma, the data are less robust. A clearer understanding of the pharmacology of n-3 PUFAs will help to establish targets to modulate chronic inflammatory diseases. (C) 2013 Elsevier Inc. All rights reserved.
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