Journal
PHARMACOLOGY & THERAPEUTICS
Volume 144, Issue 2, Pages 192-201Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2014.06.001
Keywords
GLUT1-deficiency; Ketogenic diet; Epilepsy; Metabolism; Glucose
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Funding
- Australian Future Fellowship, Australian Research Council [FT0990628]
- Dowd Fellowship
- NHMRC
- Department of Health, Victorian State Government
- Viertel Clinical Investigatorship
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Metabolic dysfunction leading to epilepsy is well recognised. Dietary therapy, in particular the ketogenic diet, is now considered an effective option. Recent genetic studies have highlighted the central role that metabolism can play in setting seizure susceptibility. Here we discuss various metabolic disorders implicated in epilepsy focusing on energy deficiency due to genetic and environmental causes. We argue that low, uncompensated brain glucose levels can precipitate seizures. We will also explore mechanisms of disease and therapy in an attempt to identify common metabolic pathways involved in modulating seizure susceptibility. Finally, newer therapeutic approaches based on diet manipulation in the context of energy deficiency are discussed. Crown Copyright (C) 2014 Published by Elsevier Inc All rights reserved.
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