Journal
PHARMACOLOGY & THERAPEUTICS
Volume 142, Issue 2, Pages 183-195Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2013.12.005
Keywords
Garlic; Organosulfur compounds; Cancer; Cardiovascular disorders; Neurological diseases; Liver diseases; Allergy; Arthritis
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Funding
- National Research Foundation of Korea (NRF)
- Korean Government (MISP) [MRC, 2008-0062275]
- Korean Health Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea [A101836]
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The medicinal properties of functionally active organosulfur compounds such as allin, diallyl disulfide, S-allylmercaptocysteine, and S-trityl-L-cysteine isolated from garlic have received great attention from a large number of investigators who have studied their pharmacological effects for the treatment of various diseases. These organosulfur compounds are able to prevent for development of cancer, cardiovascular, neurological, and liver diseases as well as allergy and arthritis. There have been also many reports on toxicities and pharmacokinetics of these compounds. The aim of this study is to review a variety of experimental and clinical reports, and describe the effectiveness, toxicities and pharmacokinetics, and possible mechanisms of pharmaceutical actions of functionally active compounds isolated from garlic. (C) 2013 Elsevier Inc. All rights reserved.
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