Journal
PHARMACOLOGY & THERAPEUTICS
Volume 132, Issue 1, Pages 15-29Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2011.05.001
Keywords
Clinical trials; Mitochondria; Riluzole; Fampridine; Minocycline; Erythropoietin
Categories
Funding
- Spinal Cord and Brain Injury Research Center
- Cardinal Hill Rehabilitation Hospital
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Despite numerous studies reporting some measures of efficacy in the animal literature, there are currently no effective therapies for the treatment of traumatic spinal cord injuries (SCI) in humans. The purpose of this review is to delineate key pathophysiological processes that contribute to neurological deficits after SCI, as well as to describe examples of pharmacological approaches that are currently being tested in clinical trials, or nearing clinical translation, for the therapeutic management of SCI. In particular, we will describe the mechanistic rationale to promote neuroprotection and/or functional recovery based on theoretical, yet targeted pathological events. Finally, we will consider the clinical relevancy for emerging evidence that pharmacologically targeting mitochondrial dysfunction following injury may hold the greatest potential for increasing tissue sparing and, consequently, the extent of functional recovery following traumatic SCI. (C) 2011 Elsevier Inc. All rights reserved.
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