Journal
PHARMACOLOGY & THERAPEUTICS
Volume 127, Issue 2, Pages 156-164Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2010.04.012
Keywords
Yeast; Chemical genomics; Chemical biology; Drug target; Drug action
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Over the past decade, the development and application of chemical genomic assays using the model organism Saccharomyces cerevisiae has provided powerful methods to identify the mechanism of action of known drugs and novel small molecules in vivo. These assays identify drug target candidates, genes involved in buffering drug target pathways and also help to define the general cellular response to small molecules. In this review, we examine current yeast chemical genomic assays and summarize the potential applications of each approach. (C) 2010 Elsevier Inc. All rights reserved.
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