Journal
TUMOR BIOLOGY
Volume 36, Issue 9, Pages 6679-6689Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-3356-8
Keywords
Nasopharyngeal carcinoma; miR-494; Tumor suppressor; GALNT7; CDK16
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Funding
- Science and Technology Development Fund Project of Shenzhen [JCYJ20120827150357364, JCYJ20130402114702127]
- Medical Research Project of the Health and Family Planning Commission of Shenzhen [201302005]
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Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.
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