Journal
PHARMACOLOGY & THERAPEUTICS
Volume 119, Issue 1, Pages 33-43Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2008.04.006
Keywords
muscarinic; acetylcholine; MDCK; epithelial; neuron; trafficking; localization; glycosylation; GPCR; membrane protein synthesis
Categories
Funding
- NHLBI NIH HHS [R01 HL058676-04, P01 HL044948-110008, R01 HL030639-17, P01 HL044948] Funding Source: Medline
- NINDS NIH HHS [R01 NS026920-17, R01 NS026920] Funding Source: Medline
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Muscarinic acetylcholine receptors are members of the G-protein coupled receptor superfamily that are expressed in and regulate the function of neurons, cardiac and smooth muscle, glands, and many other cell types and tissues. The correct trafficking of membrane proteins to the cell surface and their subsequent localization at appropriate sites in polarized cells are required for normal cellular signaling and physiological responses. This review will summarize work on the synthesis and trafficking of muscarinic receptors to the plasma membrane and their localization at the cell surface. (C) 2008 Elsevier Inc. All rights reserved.
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