Journal
TUMOR BIOLOGY
Volume 36, Issue 3, Pages 1403-1409Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-3267-8
Keywords
Non-coding RNA; miR-100; Human cancer; Diagnostic; Prognostic; Biomarker
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Funding
- National Natural Science Foundation of China [81272601, 81472198]
- Key Clinical Medicine Technology Foundation of Jiangsu Province [BL2014096]
- Medical Key Talented Person Foundation of the Jiangsu Provincial Developing Health Project [RC2011080]
- Innovation Team Project of the Second Affiliated Hospital of Nanjing Medical University [CX201202]
- 333 high class Talented Man Project [2011-III-2630]
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MicroRNAs (miRNAs) are small non-coding RNAs that function by base pairing with messenger RNAs, thereby regulating protein expression. Functional studies indicate that miRNAs are involved in the regulation of almost every biological pathway. Moreover, changes in miRNA expression are associated with several human pathologies, including cancer. Dysregulation and aberrant expression of microRNA-100 (miR-100) have been reported to be involved in tumorigenesis and tumor progression of several cancer types, suggesting that miR-100 might serve as a diagnostic and/or prognostic marker for human malignancy. In this review, we summarize the potential application of miR-100 in cancer treatment and as a new molecular marker for cancer prognosis and diagnosis. We will provide a brief introduction to miR-100 and discuss its role as a non-invasive biomarker and a potential therapeutic target in human cancers.
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