Journal
PHARMACOLOGY
Volume 90, Issue 5-6, Pages 264-273Publisher
KARGER
DOI: 10.1159/000342636
Keywords
Acetylcholine; Cholinergic Interneuron; Social Interaction; Nucleus Accumbens; Striatum; Zif268; Cocaine; Substance use disorder
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Funding
- SPIN ('Signal Processing in Neurons') graduate program [W1206-B05]
- Austrian Science Fund (FWF) [W1206] Funding Source: Austrian Science Fund (FWF)
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Converging evidence from different independent laboratories suggests that acetylcholine may play an important role in drug reward and that modulation of the cholinergic system may be useful for the treatment of substance use disorders. In this commentary, we try to reconcile apparently discrepant animal behavioral, human behavioral and clinical data with a unifying hypothesis positing that the modulation of drug-versus natural stimuli-mediated reward by cholinergic interneurons in the nucleus accumbens (and the dorsal striatum) is restricted to distinct neuron ensembles that show considerable intra-and interindividual variation with respect to their spatial distribution. The precise targeting of these interindividually variable neuron ensembles would be a prerequisite for a successful pharmacotherapy based on the modulation of the cholinergic system. We also provide experimental data to support our unifying hypothesis. Copyright (C) 2012 S. Karger AG, Basel
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