Journal
TUMOR BIOLOGY
Volume 36, Issue 8, Pages 6223-6230Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-3307-4
Keywords
Cancer stem-like cells; miR-1290; Fyn-related Src family tyrosine kinase; Non-small cell lung cancer
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Funding
- National Basic Research Program of China (973 Program) [2010CB934002]
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Cancer stem-like cells (CSLCs) are involved in cancer initiation, development, and metastasis, and microRNAs (miRNAs) play pivotal roles in regulating CSLCs. miRNA-based therapeutic strategy associated with CSLCs might promise potential new therapeutic approaches. In the present study, we found that miR-1290 was increased in CD133(+) cells. Antagomir-1290 significantly suppressed tumor volume and weight initiated by CD133(+) cells in vivo. Furthermore, antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase. These findings provide insights into the clinical prospect of miR-1290-based therapies for non-small cell lung cancer.
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