Related references
Note: Only part of the references are listed.Basis for design and development of Platinum(IV) anticancer complexes
Matthew D. Hall et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Transport kinetics of four-coordinate and six-coordinate platinum compounds in the multicell layer tumour model
S. Modok et al.
BRITISH JOURNAL OF CANCER (2007)
Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer
Shin Nakahira et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
DNA methylation as a therapeutic target in cancer
Jean-Pierre J. Issa
CLINICAL CANCER RESEARCH (2007)
Nuclear metallothionein expression correlates with cisplatin resistance of ovarian cancer cells and poor clinical outcome
Pawel Surowiak et al.
VIRCHOWS ARCHIV (2007)
Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
Y. Nakano et al.
BRITISH JOURNAL OF CANCER (2007)
Molecular basis of antifolate resistance
Yehuda G. Assaraf
CANCER AND METASTASIS REVIEWS (2007)
Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer
Stephen E. Jones et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Vinflunine: a new active drug for second-line treatment of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy
M. Campone et al.
BRITISH JOURNAL OF CANCER (2006)
A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma
Christopher W. Ryan et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
Topoisomerase I inhibitors: camptothecins and beyond
Yves Pommier
NATURE REVIEWS CANCER (2006)
Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer
Szabolcs Modok et al.
CURRENT OPINION IN PHARMACOLOGY (2006)
Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: Three-gene expression model predicts clinical response
Ryusei Matsuyama et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Mismatch repair system (MMR) status correlates with response and survival in non-small cell lung cancer (NSCLC) patients
Mario Scartozzi et al.
LUNG CANCER (2006)
The multifaceted mismatch-repair system
J Jiricny
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors -: correlation to tumor histopathology and clinical follow-up
S Lassmann et al.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2006)
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
E Giovannetti et al.
CANCER RESEARCH (2006)
Changes of topoisomerase IIα expression in breast tumors after neoadjuvant chemotherapy predicts relapse-free survival
N Tinari et al.
CLINICAL CANCER RESEARCH (2006)
Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase:: Phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors
M Ranson et al.
CLINICAL CANCER RESEARCH (2006)
Oncologic, endocrine & metabolic - Irinotecan in the treatment of small cell lung cancer: a review of patient safety considerations
Masaaki Kawahara
EXPERT OPINION ON DRUG SAFETY (2006)
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (AsP26Glu) and less stable microtubules
M Hari et al.
MOLECULAR CANCER THERAPEUTICS (2006)
From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates
J Walling
INVESTIGATIONAL NEW DRUGS (2006)
Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits
K. Smid et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2006)
Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil
M. Ciaparrone et al.
ONCOLOGY (2006)
Apoptosis effector mechanisms: A requiem performed in different keys
N. Hail et al.
APOPTOSIS (2006)
Predictive factors for response to docetaxel in human breast cancers
Shinzaburo Noguchi
CANCER SCIENCE (2006)
The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer
S Madhusudan et al.
CANCER TREATMENT REVIEWS (2005)
Human multidrug resistance associated protein 4 confers resistance to camptothecins
Q Tian et al.
PHARMACEUTICAL RESEARCH (2005)
In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant
AM Bergman et al.
CANCER RESEARCH (2005)
Profiling cytochrome P450 expression in ovarian cancer:: Identification of prognostic markers
D Downie et al.
CLINICAL CANCER RESEARCH (2005)
β-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells
Y Gökmen-Polar et al.
CANCER RESEARCH (2005)
Insights into oxazaphosphorine resistance and possible approaches to its circumvention
J Zhang et al.
DRUG RESISTANCE UPDATES (2005)
Hematologic safety and tolerability of topotecan in recurrent ovarian cancer and small cell lung cancer: An integrated analysis
DK Armstrong et al.
ONCOLOGIST (2005)
Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients
P Surowiak et al.
VIRCHOWS ARCHIV (2005)
A model of quiescent tumour microregions for evaluating multicellular resistance to chemotherapeutic drugs
HR Mellor et al.
BRITISH JOURNAL OF CANCER (2005)
Epigenetic silencing of the MGMT gene in cancer
H Soejima et al.
BIOCHEMISTRY AND CELL BIOLOGY (2005)
Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours
LH Lê et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2005)
Potential for improvement of docetaxel-based chemotherapy: a pharmacological review
FK Engels et al.
BRITISH JOURNAL OF CANCER (2005)
The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death
RN Trivedi et al.
CANCER RESEARCH (2005)
Topoisomerase Enzymes as Therapeutic Targets for Cancer Chemotherapy
Gregory I. Giles et al.
MEDICINAL CHEMISTRY (2005)
The response to cyclophosphamide in steroid-sensitive nephrotic syndrome is influenced by polymorphic expression of glutathion-S-transferases-M1 and-P1
U Vester et al.
PEDIATRIC NEPHROLOGY (2005)
Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a prognostic factor in human endometrial carcinoma
T Aida et al.
GYNECOLOGIC ONCOLOGY (2005)
MGMT gene silencing and benefit from temozolomide in glioblastoma
ME Hegi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: The Austrian breast and colorectal cancer study group
M Filipits et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia
JM Lluis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
DNA mismatch repair deficiency, resistance to cancer chemotherapy and the development of hypersensitive agents
K Pors et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2005)
Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein
EM Kemper et al.
EUROPEAN JOURNAL OF CANCER (2004)
Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: Identification of cytochrome P4502B enzymes and site-specific mutants with improved enzyme kinetics
CS Chen et al.
MOLECULAR PHARMACOLOGY (2004)
Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy
K Nakayama et al.
CLINICAL CANCER RESEARCH (2004)
Expression of cytochrome P450 in lung tumor
N Gharavi et al.
CURRENT DRUG METABOLISM (2004)
ABCC2-mediated biliary transport of 4-glutathionylcyclophosphamide and its contribution to elimination of 4-hydroxycyclophosphamide in rat
RL Qiu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
High interstitial fluid pressure -: An obstacle in cancer therapy
CH Heldin et al.
NATURE REVIEWS CANCER (2004)
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
MF Paz et al.
CLINICAL CANCER RESEARCH (2004)
The cellular response to general and programmed DNA double strand breaks
CH Bassing et al.
DNA REPAIR (2004)
Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): Resistance to docetaxel
E Hopper-Borge et al.
CANCER RESEARCH (2004)
Alkylation damage in DNA and RNA -: repair mechanisms and medical significance
F Drablos et al.
DNA REPAIR (2004)
Inhibition of NFκB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models
S Mabuchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species
KD Mansfield et al.
JOURNAL OF APPLIED PHYSIOLOGY (2004)
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
AD Schimmer et al.
CANCER CELL (2004)
Mechanisms of disease: Gene silencing in cancer in association with promoter hypermethylation
JG Herman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin
P Hautefaye et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
AM Shannon et al.
CANCER TREATMENT REVIEWS (2003)
The copper export pump ATP7B modulates the cellular pharmacology of carboplatin in ovarian carcinoma cells
K Katano et al.
MOLECULAR PHARMACOLOGY (2003)
Mutation of the class I β-tubulin gene does not predict response to paclitaxel for breast cancer
K Maeno et al.
CANCER LETTERS (2003)
Kinetic study on the reaction of cisplatin with metallothionein
D Hagrman et al.
DRUG METABOLISM AND DISPOSITION (2003)
Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma
HR Dhaini et al.
JOURNAL OF CLINICAL ONCOLOGY (2003)
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells
A Mansouri et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo
M Shionoya et al.
CANCER SCIENCE (2003)
Methylation-induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1
P Cejka et al.
EMBO JOURNAL (2003)
Phase I and pharmacokientic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumours
J Bennouna et al.
ANNALS OF ONCOLOGY (2003)
Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability
A Mrózek et al.
CELL DEATH AND DIFFERENTIATION (2003)
Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer
IC Henderson et al.
JOURNAL OF CLINICAL ONCOLOGY (2003)
Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer
SF Wen et al.
CANCER GENE THERAPY (2003)
Intratumour heterogeneity in the uptake of macromolecular therapeutic agents in human melanoma xenografts
BA Graff et al.
BRITISH JOURNAL OF CANCER (2003)
Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human gastric carcinoma
M Ohbu et al.
CANCER LETTERS (2003)
Reduced folate carrier protein expression in osteosarcoma - Implications for the prediction of tumor chemosensitivity
I Ifergan et al.
CANCER (2003)
Multivariate analysis for prognostic significance of histologic subtype, GST-pi, MDR-1, and p53 in stages II-IV ovarian cancer
K Ikeda et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2003)
Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model
MR Middleton et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes
B Plosky et al.
DNA REPAIR (2002)
Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism
GJ Peters et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2002)
Cellular roles of DNA topoisomerases: A molecular perspective
JC Wang
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Glutathione induces cellular resistance against cationic dinuclear platinum anticancer drugs
BAJ Jansen et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2002)
Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer:: a retrospective study -: Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens
NE Sládek et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2002)
Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human breast carcinoma
A Kanzaki et al.
JAPANESE JOURNAL OF CANCER RESEARCH (2002)
Multidrug resistance in cancer: Role of ATP-dependent transporters
MM Gottesman et al.
NATURE REVIEWS CANCER (2002)
Hypoxia - A key regulatory factor in tumour growth
AL Harris
NATURE REVIEWS CANCER (2002)
DNA and its associated processes as targets for cancer therapy
LH Hurley
NATURE REVIEWS CANCER (2002)
Immunohistochemical localization of metallothionein in benign and malignant epithelial ovarian tumors
WG McCluggage et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2002)
Genetic analysis of the β-tubulin gene, TUBB, in non-small-cell lung cancer
MJ Kelley et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2001)
Developments in cytotoxic chemotherapy: advances in treatment utilising vinorelbine
MS Aapro et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2001)
Transvascular and interstitial transport of a 19 kDa linear molecule in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging
I Bjornæs et al.
JOURNAL OF MAGNETIC RESONANCE IMAGING (2001)
Vinflunine, the latest Vinca alkaloid in clinical development -: A review of its preclinical anticancer properties
A Kruczynski et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2001)
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
S Fulda et al.
ONCOGENE (2001)
Vinflunine, a second generation novel Vinca alkaloid with a distinctive pharmacological profile, now in clinical development and prospects for future mitotic blockers
BT Hill
CURRENT PHARMACEUTICAL DESIGN (2001)
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death
T Teitz et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2001)
Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function
RK Jain
JOURNAL OF CONTROLLED RELEASE (2001)
Markedly diminished drug resistance-inducing properties of vinflunine (20′,20′-difluoro-3′,4′-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumour cells in vivo and in vitro
C Etiévant et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2001)
Expression of glutathione S-transferase pi (GST-pi) in human malignant ovarian tumors
T Satoh et al.
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2001)
Topoisomerase IIα and other drug resistance markers in advanced non-small cell lung cancer
AMC Dingemans et al.
LUNG CANCER (2001)
The binding conformation of Taxol in β-tubulin:: A model based on electron crystallographic density
JP Snyder et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Hypoxia inhibits G1/S transition through regulation of p27 expression
LB Gardner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
M Esteller et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
JY Douillard et al.
LANCET (2000)
Molecular basis of anthracycline-induced cardiotoxicity and its prevention
MS Horenstein et al.
MOLECULAR GENETICS AND METABOLISM (2000)
Docetaxel - An update of its use in advanced breast cancer
DP Figgitt et al.
DRUGS (2000)
Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas
D Mayr et al.
PATHOLOGY RESEARCH AND PRACTICE (2000)
Expression of hypoxia-inducible factor 1: Mechanisms and consequences
GL Semenza
BIOCHEMICAL PHARMACOLOGY (2000)