Journal
PHARMACOLOGY
Volume 82, Issue 3, Pages 193-200Publisher
KARGER
DOI: 10.1159/000156485
Keywords
AM1241; cannabinoid system; CB-1 and CB-2 receptors; diabetes; hyperalgesia; indomethacin; L-NOArg; Met-F-AEA; streptozotocin; WIN 55,212-2
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The effect of CB-1 and CB-2 receptor agonists, as well as an influence of a non-selective inhibitor of nitric oxide synthase (NOS), L-NOArg, and an inhibitor acting preferentially on cyclooxygenase-1 (COX-1), indomethacin, on the action of cannabinoid receptor agonists in a streptozotocin (STZ)-induced neuropathic model was investigated. When administered alone, a non-selective cannabinoid receptor agonist, WIN 55,212-2, a potentially selective CB-1 cannabinoid receptor agonist, Met-F-AEA, and a selective CB-2 cannabinoid receptor agonist, AM1241, dose-dependently reduced STZ- induced hyperalgesia. The results of the present study also demonstrated that inhibitors of COX and NOS increase antihyperalgesic activity of low doses of CB-1 and CB-2 receptor agonists. Hypothetical consequences of this phenomenon are discussed. Copyright (C) 2008 S. Karger AG, Basel.
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