Journal
TUMOR BIOLOGY
Volume 36, Issue 7, Pages 5291-5298Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-3189-5
Keywords
Microlocalization; CD68; Tumor associated macrophages; Prognosis; Oral squamous cell carcinoma
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Funding
- National Natural Science Foundation of China [81402238, 81072213, 81271698]
- Nanjing Medical Science & Research Project [YKK13145]
- National Key Disciplines Constructional Project Funding
- Jiangsu Provincial Clinical Medicine of Science and Technology project [BL2012017]
- Nanjing Municipal Key Medical Laboratory Constructional Project Funding
- Center of Nanjing Clinical Medicine of tumor project
- [QRX113311]
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CD68 has been widely used as a pan-macrophage marker for tumor-associated macrophages (TAM) which always involve in carcinogenesis. But the correlations between CD68(+) TAMs and prognosis of patients show to be inconsistent, which might due to lack of specific markers of TAMs. We here found that the microlocalization of CD68(+) TAMs also played a unique role in prognosis of patients with oral squamous cell carcinoma (OSCC). CD68(+) TAMs were identified in paraffin-embedded OSCC specimens (n=91) by using immunohistochemistry. The number of CD68(+) TAMs was remarkably increased from adjacent none-neoplasia tissues (NT) to tumor nest (TN), but tumor stroma (TS) was infiltrated with highest frequency of CD68(+) TAMs (P<0.0001). Unexpectedly, more CD68(+) TAMs in TS, but not NT or TN, were associated with high tumor grade (P=0.033), lymph node metastasis (P=0.034), and shorter 10-year overall survival time, disease free survival. Considering TAMs was derived from monocytes in peripheral blood, we assessed the relationship between leukocytes in peripheral blood and CD68(+) TAMs in OSCC and found that more CD68(+) TAMs in TS were accompanied with decreased monocytes and lymphocytes in peripheral blood (P<0.05). Although Cox regression analysis revealed that CD68(+) TAMs in TS were not an independent prognostic factor for OSCC patients, we raised a possibility that the microlocalization of CD68(+) TAMs was an indispensable factor for the advance of OSCC.
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