Journal
TUMOR BIOLOGY
Volume 36, Issue 7, Pages 5031-5038Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-3154-3
Keywords
miR-342-3p; Non-small cell lung cancer; RAP2B; Proliferation; Migration; Invasion
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Funding
- National Natural Science Foundation of China [81071924, 81372520]
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MicroRNAs (miRNAs) play critical roles in cancer development and progression. In this study, we examined the roles and molecular mechanisms of miR-342-3p in human non-small cell lung cancer (NSCLC). The results showed that miR-342-3p is downregulated in NSCLC cell lines and tissues, and its overexpression induces significant inhibition of NSCLC cell proliferation, invasion, and tumor growth in nude mice. In addition, miR-342-3p repressed RAP2B expression through interactions with its 3'-UTR region. Restoration of RAP2B expression reversed miR-342-3p-mediated inhibitory activity in NSCLC cells. Finally, analyses of miR-342-3p and RAP2B levels in NSCLCs revealed that miR-342-3p inversely correlated with RAP2B mRNA expression. Our collective findings provide preliminary evidence that miR-342-3p acts as a tumor suppressor in NSCLC through repression of RAP2B.
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