Journal
PHARMACOLOGICAL REPORTS
Volume 66, Issue 4, Pages 653-659Publisher
POLISH ACAD SCIENCES INST PHARMACOLOGY
DOI: 10.1016/j.pharep.2014.03.004
Keywords
Antidepressant; Creatine; Intracellular signaling; Kinases; Tail suspension test
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [307687/2009-0]
- Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)
- Fundacao de Apoio a Pesquisa Cientifica e Tecnologica do Estado de Santa Catarina (FAPESC) [1347/2010-1]
- Rede Instituto Brasileiro de Neurociencia [IBN-Net/CNPq]
- Nude de Excelencia em Neurociencias Aplicadas de Santa Catarina (NENASC) Project/PRONEX Program (CNPq/FAPESC)
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Background: The aim of this study was to investigate the involvement of signaling pathways on the creatine antidepressant-like effect in the tail suspension test (TST) in mice. Methods: The TST was used to assess the antidepressant-like properties of creatine. Results: The anti-immobility effect of creatine (1 mg/kg, p.o.) in the TST was blocked by i.c.v. pretreatment with H-89 (1 mu g/site, PKA inhibitor), KN-62 (1 mu g/site, CAMK-II inhibitor), chelerythrine (1 mu g/site, PKC inhibitor), U0126 (5 mu g/site, MEK1/2 inhibitor) or P009058 (5 mu g/site, MEK1/2 inhibitor). Conclusion: These results suggest that the antidepressant-like effect of creatine is dependent on PKA, CaMK-II, PKC and MEK 1/2 activation. (C) 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. Z o.o. All rights reserved.
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