Journal
TUMOR BIOLOGY
Volume 37, Issue 5, Pages 6769-6773Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-4586-5
Keywords
Epithelial ovarian cancer; PRSS3; WAVE1; Tissues; Expression
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In this study, we evaluate the clinical significance of the PRSS3 and Wiskott Aldrich syndrome protein family verprolin-homologous protein 1 (WAVE1) in patients with epithelial ovarian cancer (EOC) by immunohistochemistry. In current study, all adjacent non-cancerous tissues showed absent or low expression of PRSS3. The expression of PRSS3 was significantly increased in the EOCs than adjacent non-cancerous tissues. Moreover, the expression of WAVE1 was significantly observed in all EOC tissues when compared with normal tissues. Furthermore, WAVE1 expression was absent in 35 (89.74 %) adjacent non-cancerous tissues. Our findings showed that high expression of PRSS3 was markedly linked to FIGO stage (P=0.02), advanced grade (P=0.017), and lymph node metastases (P=0.001), but no relationship was determined with other clinicopathological parameters. Furthermore, high expression of WAVE I was significantly correlated with FIGO stage (P=0.001), grade of tumor (P=0.011), and residual tumor size (P=0.041), but no significant associations were found between WAVE1 expression and age, lymph node metastasis, and histological subtypes (all P>0.05). In conclusion, our study showed that increased expression of PRSS3 and. WAVE1 may be involved in development of EOC.
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