Journal
PHARMACOLOGICAL REPORTS
Volume 61, Issue 6, Pages 957-965Publisher
POLISH ACAD SCIENCES INST PHARMACOLOGY
DOI: 10.1016/S1734-1140(09)70157-4
Keywords
nicotine; drug discrimination; self-administration; reinstatement of seeking behavior; sensitization; rat; clinical trials; nicotine pharmacotherapy
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Nicotine dependence is a disease of constantly growing importance. This mini-review describes the effects of nicotine in humans and focuses on the various laboratory animal models developed to study the dependence-related behavioral effects of nicoline. In addition, we outline the Current therapeutic approaches designed to substitute nicotine from cigarette smoke with safer compounds of to relieve symptoms of nicotine withdrawal during smoking abstinence. Since several pharmacotherapies have failed to be efficacious in all patients, we also assess the clinical effectiveness of newer agents in relation to existing drugs.
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