Journal
PHARMACOLOGICAL REPORTS
Volume 61, Issue 6, Pages 1179-1183Publisher
POLISH ACAD SCIENCES INST PHARMACOLOGY
DOI: 10.1016/S1734-1140(09)70181-1
Keywords
sigma(1) receptor agonist; PRE-084; sigma(1)- and sigma(2)-receptor antagonists; BD 1047; SM 21; forced swim test; mice
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PRE-084, a selective a receptor agonist, exhibited an antidepressant-like effect in the forced swim test (FST) in Albino Swiss and C57BL/6J mice. This effect was counteracted by BD 1047 (5 and 10 mg/kg) but not by SM-21 (3 and 10 mg/kg), which are sigma(1)- and sigma(2)-receptor antagonists, respectively. The results indicated that PRE-084 has an antidepressant-like effect in C57BL/6J and, to a lesser extent, in Albino Swiss mice. These results support the idea that sigma(1)-receptors, but not sigma(2)-receptors, contribute to the mechanism of antidepressant activity of sigma agonists in FST.
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