Journal
PHARMACOLOGICAL REPORTS
Volume 61, Issue 6, Pages 1184-1191Publisher
POLISH ACAD SCIENCES INST PHARMACOLOGY
DOI: 10.1016/S1734-1140(09)70182-3
Keywords
chronic treatment; zinc; glycine/NMDA; 5-HT1A; 5-HT2A; receptors; BDNF
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Funding
- Ministry of Education and Science [2 P05A 0178 29]
- Institute of Pharmacology
- Polish Academy of Sciences and Collegium Modicum
- Jagiellonian University, Krakow
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Preclinical data indicate the involvement of glutamatergic and serotonergic pathways in the antidepressant activity of zinc. The present study investigated alterations in N-methyl-D-aspartate (NMDA)/glutamatergic and serotonergic receptors (using radioligand binding) induced by chronic treatment (14-day) with zinc hydroaspartate (65 mg/kg). Moreover, the mRNA and protein levels of brain-derived neurotrophic factor (BDNF) were also assessed. Chronic zinc administration reduced the affinity of glycine to glycine/NMDA receptors in the rat frontal cortex and increased the density of 5-HT1A and 5-HT2A serotonin receptors in the hippocampus and frontal cortex, respectively. These receptor alterations may be in part due to increased BDNF mRNA and protein levels in the rat frontal cortex. These results indicate that chronic zinc treatment alters glutamatergic and serotonergic systems, which is a hallmark of clinically effective antidepressants.
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