Journal
PHARMACOGNOSY MAGAZINE
Volume 10, Issue 38, Pages 334-341Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/0973-1296.133292
Keywords
Marine; sponge; Siphonochalina; triterpenes and anticancer
Categories
Funding
- Saudi Arabia Basic Industries Corroboration (SABIC)
- Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah [MS/13/259/1432]
- SABIC
- DSR
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Background: Siphonochalina siphonella is a marine sponge collected from saudi Red Sea water and scare study from this region. Objective: To isolate the anticancer triterpenes with potent cytotoxicity from marine sponge, Siphonochalina siphonella and state the mode of action in cancer cell lines. Materials and Methods: The sponge material was collected, extracted with organic solvent, and fractionated on different adsorbents. The structure of the pure metabolites were elucidated employing different spectroscopic techniques including 1D ( (1) H and (13) C) and 2D (COSY, HMQC and HMBC) NMR, and MS spectroscopy. Results: A new Neviotine-C (1) was obtained, along with four known metabolites (2-5). All compounds, except 5, were tested towards MCF-7, PC-3 and A549 and showed effects with IC 50 in range 7.9-87 M, whilst, 3 showed potent anti-proliferative activity against PC-3 and A549 with IC 50 = 7.9 0.120 and 8.9 0.010 M, respectively. Conclusion: Compounds (1-4) showed significant cytotoxic activities, while 3 showed potent effect. The antiproliferative of 3 was attributed to signi?cant S-phase cell cycle arrest.
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