Journal
PHARMACOGENOMICS JOURNAL
Volume 11, Issue 4, Pages 267-273Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/tpj.2010.40
Keywords
chromosome 1; pharmacogenetic; psychosis; neuroplasticity; neurodevelopment; super-refractory
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Funding
- Institut National de la Sante et de la Recherche Medicale (Inserm)
- Centre Hospitalier Sainte Anne Hospital Sainte-Anne
- Fondation Pierre Deniker
- Collaborative Network for Family Study in Psychiatry
- Fondation Pierre Deniker: Hospital Sainte-Anne
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Three common missense variants of the Disrupted in Schizophrenia 1 (DISC1) gene, rs3738401 (Q264R), rs6675281 (L607F) and rs821616 (S704C), have been variably associated with the risk of schizophrenia. In a case-control study, we examine whether these gene variants are associated with schizophrenia and ultra-resistant schizophrenia (URS) in a population of French Caucasian patients. The URS phenotype is characterized according to stringent criteria as patients who experience no clinical, social and/or occupational remission in spite of treatment with clozapine and at least two periods of treatment with distinct conventional or atypical antipsychotic drugs. We find a significant association between DISC1 missense variants and URS. The association with rs3738401 remains significant after appropriate correction for multiple testing. These results suggest that the DISC1 rs3738401 missense variant is statistically linked with ultra-resistance to antipsychotic treatment. The Pharmacogenomics Journal (2011) 11, 267-273; doi:10.1038/tpj.2010.40; published online 8 June 2010
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