Journal
PHARMACOGENOMICS
Volume 13, Issue 2, Pages 171-178Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/PGS.11.140
Keywords
chemotherapy; cisplatin; DNA polymorphism; ethnic diversity; ovarian cancer
Categories
Funding
- Federal Program Scientific and Pedagogical Cadre for Innovative Russia [P1204]
- Russian Academy of Sciences
- Ministry of Science and Technology of the Russian Federation
- Russian Foundation for Basic Research [11-04-00913]
Ask authors/readers for more resources
Aim: There is a substantial difference between Asians and Caucasians in their reaction to platinum drugs. To determine whether population-related genomics contribute to differences in patient outcomes, pharmacogenomic relevance of polymorphisms in some genes, the protein activities of which may affect aspects of cisplatin metabolism, were evaluated. Patients & methods: Nineteen polymorphisms in ten genes were tested for correlations with the efficacy and toxicity of a cisplatin-cyclophosphamide regimen in Yakut and Russian patients with ovarian cancer. Results: The CYP2E1 7632T > A polymorphism was associated with progression-free survival (p = 0.015) in Yakuts. In Russians, progression-free survival was correlated with the GSTP1 Ile105Val polymorphism (p = 0.004). Yakut patients with the GSTT1-null genotype had a higher risk for nephrotoxicity. By contrast, in the Russian group, nephrotoxicity was more frequent among patients with heterozygous ERCC1 genotypes. Severe emesis in Yakuts was independently associated with two polymorphisms in the CYP2E1 gene but in Russians, it was more common in patients with the GSTT1-null genotype. Differences in genotypic correlations with anemia were also observed. Conclusion: Significant differences in genotype distribution between Russian and Yakut women were observed for ten of the 19 polymorphisms, but none of them seemed to be a clear casual candidate and further studies involving more markers are required. Original submitted: 9 June 2011; Revision submitted: 22 September 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available