Journal
PHARMACEUTICAL STATISTICS
Volume 9, Issue 1, Pages 55-66Publisher
WILEY
DOI: 10.1002/pst.375
Keywords
compartmental models; internal dose; fisher information matrix; D-optimality; likelihood ratio test; simulation
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Funding
- Ministerio de Educacion y Ciencia and fondos FEDER [MTM2007 67211 CO3-01]
- Junta de Comunidades de Castilla-La Mancha [PAI07-0019]
- Fond Social Europeo and Junta de Comunidades de CastillaLa Mancha [FSE 2007-2013]
- Junta de Castilla y Leon [SA002B07]
- University of Castilla-La Mancha [1320080566]
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The model that describes the retention in lungs of radioisotope particles is studied in this paper, considering the situation of an accident in facilities that handle radioactive materials. Optimal times to make the bioassays are computed for D- and c-optimality, and efficiencies for the computed designs are provided and compared. Moreover, the test power is checked by means of simulations and replications. After that the inverse of the Fisher information matrix is compared to an estimation of the covariance matrix of the parameters. Finally, a study taking into consideration the randomness of the designs space is performed. Copyright (C) 2009 John Wiley & Sons, Ltd.
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