Journal
PHARMACEUTICAL RESEARCH
Volume 32, Issue 4, Pages 1161-1185Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-014-1545-6
Keywords
Blood-brain barrier; Drug delivery to the CNS; In vitro models; Targeted nanoparticles; Transcytosis
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The blood-brain barrier is a unique cell-based restrictive barrier that prevents the entry of many substances, including most therapeutics, into the central nervous system. A wide range of nanoparticulate delivery systems have been investigated with the aim of targeting therapeutics (drugs, nucleic acids, proteins) to the brain following administration by various routes. This review provides a comprehensive description of the design and formulation of these nanoparticles including the rationale behind individual approaches. In addition, the ability of currently available in-vitro BBB models to accurately predict the in-vivo performance of targeted nanoparticles is critically assessed.
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