Journal
PHARMACEUTICAL RESEARCH
Volume 31, Issue 6, Pages 1358-1376Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-013-1103-7
Keywords
drug delivery; imaging; nanoparticle; polymer; theranostics
Funding
- Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
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Nanotechnology has continuously contributed to the fast development of diagnostic and therapeutic agents. Theranostic nanomedicine has encompassed the ongoing efforts on concurrent molecular imaging of biomarkers, delivery of therapeutic agents, and monitoring of therapy response. Among these formulations, polymer-based theranostic agents hold great promise for the construction of multifunctional agents for translational medicine. In this article, we reviewed the state-of-the-art polymeric nanoparticles, from preparation to application, as potential theranostic agents for diagnosis and therapy. We summarized several major polymer formulas, including polymeric conjugate complexes, nanospheres, micelles, and dendrimers for integrated molecular imaging and therapeutic applications.
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