Journal
PHARMACEUTICAL RESEARCH
Volume 29, Issue 5, Pages 1404-1418Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-011-0628-x
Keywords
biological matrix; cesium; magnetic elimination; magnetic nanoparticles; Prussian blue; seawater
Funding
- JSPS [LS114]
- NEDO of Japan [08C46049a]
- Grants-in-Aid for Scientific Research [23590995] Funding Source: KAKEN
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To investigate the potential use of Prussian blue-coated magnetic nanoparticles, termed Prussian blueberry, to bring about the magnetic elimination of cesium. Prussian blueberry were prepared by a layer-by-layer assembly method. The morphology, structure and physical properties of the Prussian blueberry were investigated as was their ability to magnetically eliminate cesium. We confirmed that Prussian blueberry were composed of a magnetite nanoparticle-core and a Prussian blue-shell. Under a magnetic field, Prussian blueberry (5 mg) reduced the cesium concentration of seawater (3 ml) from 150 ppm to about 50 ppm; but regular Prussian blue could not magnetically eliminate cesium. Moreover, Prussian blueberry removed a similar proportion of cesium from a larger volume of seawater, and from fetal bovine serum and cow's milk. Under a magnetic field, Prussian blueberry was able to rapidly eliminate cesium from seawater and from biological matrices such as serum and milk.
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