Journal
PHARMACEUTICAL RESEARCH
Volume 28, Issue 2, Pages 413-416Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-010-0283-7
Keywords
inflammation; alpha7 nicotinic acetylcholine receptor agonists; cholinergic anti-inflammatory pathway; Jak/STAT pathway
Ask authors/readers for more resources
Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as atherosclerosis, Crohn's, Alzheimer's and diabetes. Numerous cytokines play a significant role in this process, though tumor necrosis factor (TNF) and various interleukins are thought to be among the most important regulators. These proinflammatory cytokines promote the above-described diseases by inducing endothelial cell dysfunction. In this brief commentary we will discuss some of the latest advances and discoveries in the treatment of these inflammatory diseases, making use of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available