Journal
PHARMACEUTICAL RESEARCH
Volume 27, Issue 4, Pages 544-575Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-009-0045-6
Keywords
formulation; protein stability; protein stabilization
Ask authors/readers for more resources
In 1989, Manning, Patel, and Borchardt wrote a review of protein stability (Manning et al., Pharm. Res. 6:903-918, 1989), which has been widely referenced ever since. At the time, recombinant protein therapy was still in its infancy. This review summarizes the advances that have been made since then regarding protein stabilization and formulation. In addition to a discussion of the current understanding of chemical and physical instability, sections are included on stabilization in aqueous solution and the dried state, the use of chemical modification and mutagenesis to improve stability, and the interrelationship between chemical and physical instability.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available