Journal
PHARMACEUTICAL RESEARCH
Volume 27, Issue 7, Pages 1171-1183Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-010-0110-1
Keywords
angiogenesis; anti-angiogenic therapy; anticancer drugs; dosing schedule; dual targeting; PEG-coated cationic liposome; vascular targeting
Funding
- Ministry of Education, Culture, Sports and Technology, Japan [20015033]
- Grants-in-Aid for Scientific Research [20015033] Funding Source: KAKEN
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Liposomal drug delivery systems improve the therapeutic index of chemotherapeutic agents, and the use of cationic liposomes to deliver anticancer drugs to solid tumors has recently been recognized as a promising therapeutic strategy to improve the effectiveness of conventional chemotherapeutics. This review summarizes the selective targeting of cationic liposomes to tumor vasculature, the merits of incorporating the polymer polyethylene-glycol (PEG), and the impact of the molar percent of the cationic lipid included in cationic liposomes on liposomal targeting efficacy. In addition, the discussion herein includes the therapeutic benefit of a dual targeting approach, using PEG-coated cationic liposomes in vascular targeting (of tumor endothelial cells), and tumor targeting (of tumor cells) of anticancer drugs. Cationic liposomes have shown considerable promise in preclinical xenograft models and are poised for clinical development.
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