Journal
PHARMACEUTICAL RESEARCH
Volume 25, Issue 10, Pages 2387-2399Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-008-9618-z
Keywords
delivery; injectable; platelet-derived growth factor; polyurethane; scaffold
Funding
- United States Army Institute for Surgical Research [DOD-W81XWH-06-1 0654]
- Orthopaedic Trauma Research Program [DODW81XWH07 -1-0211]
- Vanderbilt Skin Diseases Research Core Center [NIH-AR41943]
- Department of Veterans Affairs
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Purpose. The purpose of this work was to investigate the effects of triisocyanate composition on the biological and mechanical properties of biodegradable, injectable polyurethane scaffolds for bone and soft tissue engineering. Methods. Scaffolds were synthesized using reactive liquid molding techniques, and were characterized in vivo in a rat subcutaneous model. Porosity, dynamic mechanical properties, degradation rate, and release of growth factors were also measured. Results. Polyurethane scaffolds were elastomers with tunable damping properties and degradation rates, and they supported cellular infiltration and generation of new tissue. The scaffolds showed a two-stage release profile of platelet-derived growth factor, characterized by a 75% burst release within the first 24 h and slower release thereafter. Conclusions. Biodegradable polyurethanes synthesized from triisocyanates exhibited tunable and superior mechanical properties compared to materials synthesized from lysine diisocyanates. Due to their injectability, biocompatibility, tunable degradation, and potential for release of growth factors, these materials are potentially promising therapies for tissue engineering.
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