Journal
PHARMACEUTICAL CHEMISTRY JOURNAL
Volume 46, Issue 2, Pages 96-102Publisher
SPRINGER
DOI: 10.1007/s11094-012-0741-0
Keywords
cyclic dipeptides; cycloprolylglycine; nootropic activity; anxiolytic activity
Categories
Ask authors/readers for more resources
A series of analogs and homologs of the endogenous cyclic dipeptide cycloprolylglycine were synthesized. The nootropic properties of the synthesized compounds were investigated on an experimental model of a passive avoidance test with electroshock- or scopolamine-induced amnesia. The anxiolytic activity was examined by an elevated plus-maze test. It is established that the pharmacophores responsible for the nootropic and anxiolytic activities are different. Hypotheses concerning the structure of the binding regions with the corresponding pharmacological targets are formulated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available