STUDIES OF THE ANTIOXIDANT AND ANTIHEMOLYTIC ACTIVITY OF QUINOLINE DERIVATIVES IN A MODEL OF OXIDATIVE DAMAGE TO ERYTHROCYTE MEMBRANES

New benzo-substituted 4-(aminophenylamino)-2-methylquinolines, 3-substituted 4-hydroxy(chloro and mercapto)quinolines, and thienoquinolines were synthesized. A model system based on oxidative damage to erythrocyte membranes induced by the combined actions of hydrogen peroxide and ionizing radiation was used to study the antihemolytic effects of these compounds as a means of assessing their antiradical/antioxidant properties. In the absence of x-rays, substances of the 3-substituted 4-hydroxy(chloro and mercapto)quinoline and thienoquinoline series were found to have marked antihemolytic effects, associated with significant influences on the structural stability of erythrocytes. However, with irradiation, the membrane-protecting effects were more marked with benzo-substituted 4-(aminophenylamino)-2-methylquinoline derivatives.