Journal
TUBERCULOSIS
Volume 95, Issue 2, Pages 91-94Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2014.12.007
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Funding
- Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India [BT/01/CoE/07/02]
- Indian Institute of Technology Delhi
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Whole Genome Sequencing (WGS) is emerging as a very powerful tool for the management, outbreak analyses, surveillance and determining drug resistance of human infectious pathogens including Mycobacterium tuberculosis and MRSA. WGS can also discriminate relapse TB from re-infection and the resolution provided by WGS has no comparison to conventional technologies. With current cost coming down to <70 pound per bacterial genome, WGS has emerged as an alternative to all the existing technologies put together. We discuss the advantage and disadvantages of WGS and whether it can become a point of care tool in not just developed countries but also in developing countries which have a huge TB burden. The likely utility of WGS for other pathogens and also in characterizing holobionts is also discussed. (C) 2014 Elsevier Ltd. All rights reserved.
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