Journal
PHARMACEUTICAL BIOLOGY
Volume 49, Issue 4, Pages 396-402Publisher
INFORMA HEALTHCARE
DOI: 10.3109/13880209.2010.519390
Keywords
Alkaloids; antimicrobial activity; antiviral activity; flavonoids; herpes simplex; parainfluenza; phenolic acids
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Materials and methods: Antiviral activity of the compounds was tested against DNA virus herpes simplex type 1 and RNA virus parainfluenza (type-3). Cytotoxicity of the compounds was determined using Madin-Darby bovine kidney and Vero cell lines, and their cytopathogenic effects were expressed as maximum non-toxic concentration. Antibacterial activity was assayed against following bacteria and their isolated strains: Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis, although they were screened by microdilution method against two fungi: Candida albicans and Candida parapsilosis. Results: Atropine and gallic acid showed potent antiviral effect at the therapeutic range of 0.8--0.05 mu A mu g ml
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