Journal
PHARMACEUTICAL BIOLOGY
Volume 48, Issue 4, Pages 417-421Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/13880200903150427
Keywords
Diuretic; oleanolic acid; potassium sparing; polyphenolics; Viscum angulatum
Funding
- All India Council for Technical Education, New Delhi [8023/BOR/RID/RPS/16/7/8]
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Viscum angulatum Heyne ex DC (Viscaceae) is a leafless hemiparasitic shrub traditionally used in Asian countries for the treatment of hypertension. In the present study, the methanol extract of the whole plant was examined for diuretic activity in rats. The activity was evaluated using parameters such as urine volume after 5, 19, and 24 h and urine sodium, potassium, and chloride concentrations. The extract was further scrutinized for polyphenolic compounds and triterpenoids. The extract demonstrated a significant increase in and dose-dependent effect on urine excretion volume in comparison to the normal group in the tested range of 100-400 mg/kg. The extract demonstrated comparable saluretic and higher natriuretic activity (Na
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