Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 462, Issue 2, Pages 195-208Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-011-0975-9
Keywords
Ca2+-activated Cl- currents; CaCC; TMEM16A; Ano 1; Anoctamin; TMEM16B; TMEM16E; TMEM16F; TMEM16G; TMEM16H; TMEM16J; TMEM16K; Cystic fibrosis; Proliferation; Cancer; Development, SHH
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Funding
- DFG [SFB699/A7]
- TargetScreen2 [EU-FP6-2005-LH-037365]
- Deutsche Krebshilfe [7207561]
- Mukoviszidose e.V. [S02/10]
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Endogenous Ca2+-activated Cl-channels (CaCC) demonstrate biophysical and pharmacological properties that are well represented in cells overexpressing anoctamin 1 (Ano 1, TMEM16A), a protein that has been identified recently as CaCC. Proteins of the anoctamin family (anoctamin 1-10, TMEM16A-K) are widely expressed. The number of reports demonstrating their physiological and clinical relevance is quickly rising. Anoctamins gain additional interest through their potential role in cell volume regulation and malignancy. Available data suggest that Ano 1 forms stable dimers and probably liaise with accessory proteins such as calmodulin or other anoctamins. In order to understand how anoctamins produce Ca2+-activated Cl- currents, it will be necessary to obtain better insight into their molecular structure, interactions with partner proteins, and mode of activation.
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