Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 458, Issue 5, Pages 869-876Publisher
SPRINGER
DOI: 10.1007/s00424-009-0682-y
Keywords
Inositol 1,4,5-trisphosphate; Pancreatic beta-cell; Endothelin; Cholecystokinin; Ca2+-induced Ca2+ release; Ion channel; Ca2+ mobilisation; Ca2+ stores; Calcium signalling; Calcium transient
Categories
Funding
- American Heart Association
- British Heart Foundation
- US National Institutes of Health
- Wellcome Trust
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In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca2+ mobilisation. In addition, we describe how TPCs may also trigger further Ca2+ release by coupling to the endoplasmic reticular stores through activation of IP3 receptors and ryanodine receptors.
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