Journal
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
Volume 107, Issue 1, Pages 1-7Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2013.05.014
Keywords
Sulfoxaflor; Sulfoximines; Mode of action; Cross-resistance; Structure activity relationships; Neonicotinoid resistance
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The sulfoximines, as exemplified by sulfoxaflor ([N-Imethyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-lambda(4)-sulfanylidene]cyanamide] represent a new class of insecticides. Sulfoxaflor exhibits a high degree of efficacy against a wide range of sap-feeding insects, including those resistant to neonicotinoids and other insecticides. Sulfoxaflor is an agonist at insect nicotinic acetylcholine receptors (nAChRs) and functions in a manner distinct from other insecticides acting at nAChRs. The sulfoximines also exhibit structure activity relationships (SAR) that are different from other nAChR agonists such as the neonicotinoids. This review summarizes the sulfoximine SAR, mode of action and the biochemistry underlying the observed efficacy on resistant insect pests, with a particular focus on sulfoxaflor. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
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