Journal
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
Volume 104, Issue 3, Pages 187-191Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2012.07.009
Keywords
Glyphosate; In vivo P-31 NMR; Metabolic flux; MEP pathway; Conyza canadensis; Lolium spp
Categories
Funding
- Monsanto Company
Ask authors/readers for more resources
Glyphosate is the world's most important and widely used herbicide with a global market forecast to exceed a million metric tons before end of the current decade. While using P-31 NMR in vivo to determine the fate of glyphosate in horseweed (Conyza canadensis (L.) Cronquist), we observed the glyphosate-induced appearance of an unexpected phosphorous containing compound that, in some cases, presented at millimolar concentrations [X. Ge, D.A. d'Avignon, J.J.H. Ackerman, R.D. Sammons, Rapid vacuolar sequestration: the horseweed glyphosate resistance mechanism, Pest Manag. Sci. 66 (2010) 345-348.]. Additional studies showed appearance of the same compound could be induced in ryegrass (Lolium multiflorum Lam) and other plant species by glyphosate exposure. We have isolated and identified the phosphorous containing compound as 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate (MEcPP), one of the intermediates of the methylerythritol 4-phosphate (MEP) pathway, which is critical in plants for the production of isoprenoids. Herein, we describe conditions under which MEcPP can be produced in plants as well as the isolation and characterization of this metabolite. (c) 2012 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available