Journal
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
Volume 90, Issue 1, Pages 26-30Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2007.07.005
Keywords
Ostrinia nubilalis; indoxacarb; oxadiazine; DEF; synergist; insecticide metabolism
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The toxicity of the oxadiazine insecticide indoxacarb to the European corn borer, Ostrinia nubilalis (Hubner) (Lepidoptera: Crambidae), was evaluated in the presence and absence of S,S,S-tributyl phosphorotrithioate (DEF), an inhibitor of hydrolytic metabolism. Bioassays involving topical application of different concentrations of indoxacarb to third instars; of a susceptible O. nubilalis laboratory strain were performed, and in vitro metabolism experiments involving [C-14] indoxacarb were examined to determine the role of hydrolytic metabolism in indoxacarb activation. Indoxacarb toxicity decreased in the presence of DEF indicating antagonism of toxicity. Results of in vivo and in vitro inhibition experiments indicated a reduction of indoxacarb activation and formation of the hydrolytic metabolite. These results are consistent with the proposed mechanism of hydrolytic activation for this compound. (c) 2007 Elsevier Inc. All rights reserved.
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