Journal
PEST MANAGEMENT SCIENCE
Volume 65, Issue 2, Pages 150-154Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/ps.1661
Keywords
PBO; PBO analogues; esterase; synergist; resistance; cytochrome P450
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Funding
- Endura SpA., Italy
- Biotechnology and Biological Sciences Council of the United Kingdom
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BACKGROUND: Previous work has demonstrated that piperonyl butoxide (PBO) not only inhibits microsomal oxidases but also resistance-associated esterases. The ability to inhibit both major metabolic resistance enzymes makes it an ideal synergist to enhance xenobiotics but negates the ability to differentiate which enzyme group is responsible for conferring resistance. RESULTS: This study examines an analogue that retains the ability to inhibit esterases but is restricted in its ability to act on microsomal oxidases, thus allowing an informed decision on resistance enzymes to be made when used in conjunction with the parent molecule. CONCLUSION: Using examples of resistant insects with well-characterised resistance mechanisms, a combination of PBO and analogue allows identification of the metabolic mechanism responsible for conferring resistance. The relative potency of PBO as both an esterase inhibitor and an oxidase inhibitor is also discussed. (C) 2008 Society of Chemical Industry
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