Journal
PEST MANAGEMENT SCIENCE
Volume 64, Issue 11, Pages 1126-1130Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/ps.1617
Keywords
DDT; voltage-gated sodium channel; pyrethroid; IIS6 helix; IIS4-S5 linker; computer modelling
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Funding
- Biotechnology and Biological Sciences Research Council [BB/F009143/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/C/00004343, BB/F009143/1] Funding Source: Medline
- BBSRC [BB/F009143/1] Funding Source: UKRI
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Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes. The correct functioning of these channels is essential for the normal transmission of nerve impulses, and this process is disrupted by binding of the insecticides, leading to paralysis and eventual death. Some insect pest populations have evolved modifications of the sodium channel protein that inhibit the binding of the insecticide and result in the insect developing resistance. This perspective outlines the current understanding of the molecular processes underlying target-site resistance to these insecticides (termed kdr and super-kdr), and how this knowledge may in future contribute to the design of novel insecticidal compounds. (c) 2008 Society of Chemical Industry
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