Journal
PERFUSION-UK
Volume 23, Issue 3, Pages 165-171Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0267659108098215
Keywords
CABG; off-pump; on-pump; surgery; syndecan-1
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The glycocalyx covering the endothelium is shed during ischemia and reperfusion. The shedding is accompanied by increased levels of the glycocalyx component syndecan- 1 in the circulation. Our aim was to compare plasma levels of syndecan- 1 in patients undergoing coronary artery bypass grafting (CABG), with or without the use of cardiopulmonary bypass (CPB). Syndecan- 1 plasma concentrations were measured in patients undergoing CABG on- pump (n = 22) or off- pump (n = 22). The syndecan- 1 concentration increased significantly from 29.5 +/- 4.6 ng/mL at baseline to 98.7 +/- 9.8 ng/mL (p < 0.01) after the start of CPB or 30 minutes after the induction of anesthesia in the off-pump group. There were no significant differences in peak syndecan-1 plasma concentrations between on-pump and off-pump patients. Plasma levels of syndecan-1 increased significantly during CABG, with or without the use of CPB. There were no significant differences in syndecan-1 concentrations in the two groups. Perfusion (2008) 23, 165-171.
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